If you use it over your entire face every day, you can expect the bottle to last 3 to 4 weeks. However if you use it only on problem areas or save it for special occasions, it will last a very long time. Shelf time is approximately three years. If you have left it unused for a long time give it a good shake to distribute the ingredients. The serum can solidify in very cold conditions or deconstruct in very hot conditions. If this happens just gently bring it to normal temperature around 20 – 25c (68 – 77f), give the bottle a very thorough shaking as the ingredients may have separated.